Can I Mix CBD Oil With Medications?

cbd and other medications

Updated Date: February 23rd 2023

CBD oil is becoming increasingly popular as a natural, holistic remedy for many ailments. 

But what medications should not be mixed with CBD oil, and why? 

This guide will cover what you need to know about mixing CBD oil with certain medications and what to watch out for.

What Is CBD Oil?

Cannabidiol (CBD) is a compound derived from the Cannabis sativa plant that has been used for centuries to address issues ranging from pain management to anxiety relief. 

It does not contain tetrahydrocannabinol (THC), the psychoactive ingredient in marijuana that gets users “high,” so people of all ages can safely use it. 

CBD oil is typically extracted from the hemp plant, and what makes it different from other cannabis products is that it contains less than 0.3% THC.

What Medications Should Not Be Mixed With CBD Oil?

Though it is generally considered safe to use CBD oil on its own, certain medications should never be mixed with CBD oil. 

The most important thing to remember when considering whether or not to mix your medications with CBD oil is to consult your doctor first. 

They can advise based on your current medication and conditions you might have that could benefit from CBD oil.

Most commonly prescribed medications can interact negatively with CBD oil, especially those that are metabolized by what is known as the cytochrome P450 enzyme system. This includes many medicines for high blood pressure, diabetes, and psychiatric disorders. 

If you take any of these medications, you must speak with your doctor before using CBD oil to avoid severe side effects.

In addition to medications metabolized by the cytochrome P450 enzyme system, certain other drugs should never be taken with CBD oil – this list includes certain antihistamines and antibiotics, among others. 

It is always essential to consult your physician before mixing any medication with CBD oil, as there could be potentially dangerous interactions between the two substances.


CBD oil is a safe, natural remedy that can relieve various ailments, but it is essential to understand what medications should not be mixed with CBD oil before using it. 

Be sure to speak with your doctor about what medications you are taking and what conditions you may have to avoid any potential interactions and side effects.

For more information on what medications should not be mixed with CBD oil, please visit the following authoritative resources:

By following these guidelines, you can ensure that you are using CBD oil safely and effectively to get the most out of your treatments.

If you’re looking for a good product, check out the article we did called best CBD oil for Lupus.

Written by Jenny Martin, CBD Journalist

Medically Reviewed by Kimberly Langdon, MD