The Effects Of CBD Oil On Lupus

endocannabinoid system

Updated Date: September 20th 2022

Are you wondering what the effects of CBD oil are on Lupus?

In this article, you're going to find out precisely that.

Living With Lupus

Lupus is a chronic and potentially deadly disease. The body's immune system goes rogue and attacks its tissues, causing Lupus.

Internal organs, including the brain, heart, and lungs, can begin to deteriorate during lupus flare-ups.

Patients may become so exhausted and sore that they are unable to do the simplest of tasks such as walking, cooking, or reading because of the illness.

In addition, because Lupus makes people sensitive to sunburn, many can't go outside without additional protection from sunscreen.

Lupus affects about 240,000 people in the United States today, yet doctors still do not know the cause or a cure.

So instead of treating the disease, doctors prescribe medicines to relieve symptoms and minimize flare-ups to avoid organ damage. 

How CBD Works In The Body

Cannabidiol, or CBD, is a cannabinoid found in cannabis. Cannabinoids are chemical compounds that bind to CB1 and CB2 receptors, which can be found throughout the body.

The majority of CB1 receptors are located in the brain, musculoskeletal system, connective tissues, gonads, glands, organs, and blood vessels; the majority of CB2 receptors are in the immune system (including the spleen), liver, heart, kidneys, bones.

When these cannabinoids bind to the receptors, they can stimulate or block specific neurotransmitters (chemical messengers sent from the brain to the rest of the body), reduce inflammation, assist digestion, and even alter the mood.

Our bodies have their endocannabinoid system, but cannabinoids found in nature are most abundant in the marijuana plant.

THC (tetrahydrocannabinol) and CBD (cannabidiol) are two of the most well-known types of cannabinoids in the marijuana plant.

THC binds to both CB1 and CB2 receptors. However, it appears that the CB1 receptor is responsible for many of marijuana's known psychoactive marijuana as euphoria, increased heart rate, slower reaction times, and red eyes.

CBD binds to the CB2 receptor, which causes a sequence of proteins called "resolvins" to be formed. (These "molecules" are known as "resolvins" because they seem to "reduce in "lamination.)

The Effects Of CBD Oil On Lupus

Dr Koumpouras acquired knowledge of ajulemic acid, a side-chain analogue of Δ8-THC-11-oic acid, which was designed as a potent therapeutic agent free of the psychotropic adverse effects that are typical with most cannabinoids from a colleague.

This chemical may aid in the treatment of pain and inflammation in systemic lupus erythematosus (SLE), which is the most prevalent form of Lupus.

"For patients with lupus, reducing "g inflammation is critical since it causes scar tissue build-up in vital organs, which can eventually lead to their deterioration and malfunction," he adds.

This cannabinoid co" pound has previously been investigated for other diseases such as systemic sclerosis and dermatomyositis.

Research On The Effects Of CBD Oil & Lupus

Dr Koumpouras is a medical doctor who has been researching the potential benefits of cannabis for people with Lupus since at least 2016.

In 2018, he became part of a multi-site randomized clinical trial. A trial will look to recruit 100 individuals and examine whether a drug is composed of a synthetically manufactured cannabinoid molecule.

A molecule that binds preferentially to CB2 receptors (called Lenabasum) can help reduce pain and inflammation in persons with Lupus.

Participants will receive Lenabasum or a placebo for almost three months, after which they will be monitored for pain and inflammation levels and lupus disease activity. The study is still ongoing, but Dr Koumpouras expects it to wrap up early next year.

Written by Jenny Martin, CBD Journalist

Medically Reviewed by Kimberly Langdon, MD

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